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Joshua Little

Saint Louis University Medical School

Contact Details

Saint Louis University Medical School

Bio

I am an Assistant Professor at Saint Louis University where I perform research on the neurobiology of pain and teach in neuroscience courses for medical, graduate, and allied health professional students. Away from work I really enjoy spending time with my family. My laboratory focuses on examining the underlying mechanisms of chronic pain. During chronic pain states, the central nervous system undergoes pathophysiological changes that result in alterations in the communication between the brain and spinal cord, which enhances the processing of nociceptive information. In the Little laboratory, we examine how these pathophysiological changes occur in multiple chronic pain states, focusing on musculoskeletal pain. We are currently optimizing animal models of chronic low back pain (CLBP) to examine the mechanisms that alter spinal and supraspinal nociceptive processing and contribute to CLBP. Another exciting aspect of the Little laboratory is our collaboration with the laboratory of Daniela Salvemini, PhD, and her award-winning work to study and target nitroxidative, sphingolipid and adenosine pathways for the relief of opioid-induced tolerance and chronic neuropathic pain, especially following chemotherapy.

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